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Product Name
Human TIRAP Recombinant protein (His tag)
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Description
Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6. {PubMed:18292575, PubMed:19509286}.
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Protein name
Toll/interleukin-1 receptor domain-containing adapter protein
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Protein short names
MAL
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Uniprot ID
P58753
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Gene Name
TIRAP; MAL
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
1-235 aa encoded by BC032474 was inserted into PET28a vector
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human TIRAP SDS-PAGE
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