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Product Name
Human TXNRD1 (aa 161-647, His Tag) recombinant protein
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Description
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
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Protein name
Thioredoxin reductase 1, cytoplasmic
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Protein short names
TXNRD1; TXNR; TR; TR1; MGC9145; TRXR1; GRIM-12
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Uniprot ID
Q16881
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Gene Name
TXNRD1; GRIM12; KDRF
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human TXNRD1 isoform 1 (Q16881-1) (Tyr 161-Cys 647) was expressed, with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human TXNRD1 consisting of 498 amino acids and has a calculated molecular mass of 55 kDa. It migrates as an 60 kDa band in SDS-PAGE under reducing conditions as predicted.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human TXNRD1 / TRXR1 Protein (aa 161-647, His Tag) SDS-PAGE
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