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Product Name
Anti-TXNRD1 Rabbit antibody
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Description
TXNRD1 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
TR; TR1; TXNR; TRXR1; GRIM-12 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human TXNRD1
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000-1/5000
IHC: 1/20
ICC/IF: 1/20
FC: 1/20-1/100
IP: 1/20
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Validations
Western blot detection of TXNRD1 in K562,Hela cell lysates using TXNRD1 Rabbit pAb(1:1000 diluted).Predicted band size:67kDa.Observed band size:55kDa.
Immunohistochemistry of TXNRD1 in paraffin-embedded Human lung cancer tissue using TXNRD1 Rabbit pAb at dilution 1/20
Immunocytochemistry of TXNRD1(green) in Hela cells using TXNRD1 Rabbit pAb at dilution 1/50, and DAPI(blue)
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Background
Swiss-Prot Acc.Q16881.Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.
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