Rhesus TGFBR2 (Fc Tag) recombinant protein

Rhesus TGFBR2 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

TGF-beta receptor type-2

TGFBETA-RII; RIIC; MFS2; TGFR-2; TBETAR-II; TAAD2; LDS2B; RIIDN; FAA3; AU042018; AAT3; TBETARII; LDS1B; DNIIR; TGFBR2; 1110020H15RIK; TBR-II; LDS2

F6Q1B1

TGFBR2

Human Cells

A DNA sequence encoding the rhesus TGFBR2 (NP_001248080.1) (Met1-Arg159) was expressed with the Fc region of human IgG1 at the C-terminus.

Rhesus

The recombinant rhesus TGFBR2 comprises 377 amino acids and has a calculated molecular mass of 42.4 KDa.

> 95 % as determined by SDS-PAGE

1. Measured by its binding ability in a functional ELISA.
2. Immobilized Rhesus TGFB1-His (Cat:504900) at 10 μg/mL (100 μL/well) can bind Rhesus TGFBR2-Fc.
The EC₅₀ of Rhesus TGFBR2-Fc is 28-56 ng/mL.