TFAP2A,AP-2 antibody

TFAP2A,AP-2 antibody

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TFAP2A,AP-2 Rabbit Polyclonal antibody. Positive WB detected in MCF7 cells, HeLa cells. Observed molecular weight by Western-blot: 47 kDa

ELISA, WB

Human,Mouse,Rat; other species not tested.

Activator protein 2 antibody; AP 2 antibody; AP 2 transcription factor antibody; AP 2alpha antibody; AP2 antibody; AP2 alpha antibody; AP2TF antibody; BOFS antibody; FLJ51761 antibody; TFAP2 antibody; TFAP2A antibody

Rabbit IgG

This antibody was obtained by immunization of TFAP2A,AP-2 recombinant protein (Accession Number: NM_001032280). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The activator protein-2 (AP-2) family of transcription factors comprises five 52-kDa isoforms (AP-2α, AP-2β, AP-2γ, AP-2δ, and AP-2ε), which share a common structure: a proline/glutamine-rich transactivation domain in the N-terminal region and a helix-span-helix domain in the C-terminal region, which mediates dimerization and site-specific DNA binding. Depending on the cellular context, the AP-2 transcription factors are individually associated either with cell differentiation and development or with cancer progression/regression. [PMID:21966377] TFAP2A (AP-2-alpha) is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation [PMID:11694877]

• Lu ZP, Xiao ZL, Yang Z. Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factor AP2α and sphingosine kinase 1. Acta pharmacologica Sinica. 36(10):1228-36. 2015.