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  • Anti-AP-2-alpha Rabbit antibody

Anti-AP-2-alpha Rabbit antibody

Cat.#: 169009

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-AP-2-alpha Rabbit antibody
  • Documents
  • Description
    AP-2-alpha Rabbit monoclonal antibody
  • Tested applications
    WB, ICC/IF, FC, IP
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    AP-2; BOFS; AP2TF; TFAP2; AP-2alpha antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human AP2 alpha
  • Clonality
    Monoclonal antibody
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000-1/5000

    ICC/IF: 1/50-1/200

    FC: 1/20

    IP: 1/20-1/50

  • Validations

    Western blot detection of AP-2-alpha in C6 cell lysates using AP-2-alpha Rabbit mAb(1:1000 diluted).Predicted band size:48kDa.Observed band size:48kDa.

    Western blot detection of AP-2-alpha in C6 cell lysates using AP-2-alpha Rabbit mAb(1:1000 diluted).Predicted band size:48kDa.Observed band size:48kDa.

  • Background
    Swiss-Prot Acc.P05549.Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"