Anti-AP-2-alpha Rabbit antibody
AP-2-alpha Rabbit monoclonal antibody
WB, ICC/IF, FC, IP
Human, Mouse, Rat
AP-2; BOFS; AP2TF; TFAP2; AP-2alpha antibody
Antigen: A synthetic peptide of human AP2 alpha
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
Western blot detection of AP-2-alpha in C6 cell lysates using AP-2-alpha Rabbit mAb(1:1000 diluted).Predicted band size:48kDa.Observed band size:48kDa.
Swiss-Prot Acc.P05549.Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
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