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Product Name
Human TFAP2A,AP-2 Recombinant protein (His tag)
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Description
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {PubMed:11694877, PubMed:12586840}.
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Protein name
Transcription factor AP-2-alpha
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Protein short names
AP2TF; TFAP2
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Uniprot ID
A0A6E1XE14
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Gene Name
TFAP2A; AP2TF; TFAP2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human TFAP2A (NP_001358995.1) 87-439 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human TFAP2A,AP-2 SDS-PAGE
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