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Product Name
Human TSPAN1 (aa 110-211, Fc Tag) recombinant protein
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Description
TSPAN1 belongs to the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins have four hydrophobic domains, intracellular N- and C-termini and two extracellular domains. Tetraspanins act as scaffolding proteins, anchoring multiple proteins to one area of the cell membrane. They also mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN1 interacts with human thiamine transporter-1 (hTHTR-1). HTHTR-1 contributes to intestinal thiamine uptake, and its function is regulated at both the transcriptional and posttranscriptional levels. TSPAN1 and hTHTR-1 colocalize in human intestinal epithelial HuTu-80 cells. Coexpression of TSPAN1 in these cells led to a significant decrease in the rate of degradation of hTHTR-1 compared with cells expressing the hTHTR-1 alone; in fact the half-life of the TSPAN1 protein was twice longer in the former cell type compared with the latter cell type.
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Protein name
Tetraspanin-1
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Protein short names
TETRASPANIN 1; TSPAN-1; NET1; RP23-319H15.4; TM4C; TETRASPAN 1; 9030418M05RIK; TSPAN1; TM4SF
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Uniprot ID
O60635
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Gene Name
TSPAN1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human TSPAN1 (O60635)(Tyr110-Asn211) was expressed with the Fc region of rabbit IgG at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human TSPAN1 comprises 351 amino acids and has a predicted molecular mass of 39.1 kDa. The apparent molecular mass of the protein is approximately 43-53 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human TSPAN1 Protein (aa 110-211, Fc Tag) SDS-PAGE
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