Anti-TSPAN1 antibody

Cat.#: 106617

Special Price 145.0 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Anti-TSPAN1 antibody
  • Documents
  • Description
    Rabbit polyclonal to TSPAN1
  • Tested applications
    ELISA, IHC-P
  • Species reactivity
    Human TSPAN1
  • Alternative names
    9030418M05Rik antibody; NET1 antibody; RP23-319H15.4 antibody; tetraspan 1 antibody; tetraspan 1 antibody; tetraspanin 1 antibody; tetraspanin 1 antibody; TM4C antibody; TM4SF antibody; TSPAN1 antibody; Tspan1 antibody; tspan-1 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human TSPAN1 (rh TSPAN1; O60635; Tyr110-Asn211). TSPAN1 specific IgG was purified by Human TSPAN1 affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    ELISA:0.1-0.2 μg/mL

    This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human TSPAN1. The detection limit for Human TSPAN1 is < 0.039 ng/well.

    IHC-P: 0.5-2 μg/ml

  • Validations

    TSPAN1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    TSPAN1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    TSPAN1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    TSPAN1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    TSPAN1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    TSPAN1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

  • Background
    TSPAN1 belongs to the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins have four hydrophobic domains, intracellular N- and C-termini and two extracellular domains. Tetraspanins act as scaffolding proteins, anchoring multiple proteins to one area of the cell membrane. They also mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN1 interacts with human thiamine transporter-1 (hTHTR-1). HTHTR-1 contributes to intestinal thiamine uptake, and its function is regulated at both the transcriptional and posttranscriptional levels. TSPAN1 and hTHTR-1 colocalize in human intestinal epithelial HuTu-80 cells. Coexpression of TSPAN1 in these cells led to a significant decrease in the rate of degradation of hTHTR-1 compared with cells expressing the hTHTR-1 alone; in fact the half-life of the TSPAN1 protein was twice longer in the former cell type compared with the latter cell type.
  • References
    • Chen L. et al., 2010, J Korean Med Sci. 25 (10): 1438-42.
    • Chen L. et al., 2010, Tumori. 96 (5): 744-50.
    • Nabokina SM. et al., 2011, Am J Physiol Gastrointest Liver Physiol. 301 (5): G808-13.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"