Anti-TSPAN1 antibody

Anti-TSPAN1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to TSPAN1

ELISA, IHC-P

Human TSPAN1

9030418M05Rik antibody; NET1 antibody; RP23-319H15.4 antibody; tetraspan 1 antibody; tetraspan 1 antibody; tetraspanin 1 antibody; tetraspanin 1 antibody; TM4C antibody; TM4SF antibody; TSPAN1 antibody; Tspan1 antibody; tspan-1 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human TSPAN1 (rh TSPAN1; O60635; Tyr110-Asn211). TSPAN1 specific IgG was purified by Human TSPAN1 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

TSPAN1 belongs to the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins have four hydrophobic domains, intracellular N- and C-termini and two extracellular domains. Tetraspanins act as scaffolding proteins, anchoring multiple proteins to one area of the cell membrane. They also mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN1 interacts with human thiamine transporter-1 (hTHTR-1). HTHTR-1 contributes to intestinal thiamine uptake, and its function is regulated at both the transcriptional and posttranscriptional levels. TSPAN1 and hTHTR-1 colocalize in human intestinal epithelial HuTu-80 cells. Coexpression of TSPAN1 in these cells led to a significant decrease in the rate of degradation of hTHTR-1 compared with cells expressing the hTHTR-1 alone; in fact the half-life of the TSPAN1 protein was twice longer in the former cell type compared with the latter cell type.

• Chen L. et al., 2010, J Korean Med Sci. 25 (10): 1438-42.
• Chen L. et al., 2010, Tumori. 96 (5): 744-50.
• Nabokina SM. et al., 2011, Am J Physiol Gastrointest Liver Physiol. 301 (5): G808-13.