Product Name

SORLA antibody

Documents

Description

SORLA Rabbit Polyclonal antibody. Positive IHC detected in human brain tissue, rat brain tissue. Positive IP detected in mouse brain tissue. Observed molecular weight by Western-blot: 300 kDa

Tested applications

ELISA, IP, IHC

Species reactivity

Human, Mouse, Rat; other species not tested.

Alternative names

LR11 antibody; LRP9 antibody; SORL1 antibody; SORLA antibody; SorLA 1 antibody; Sortilin related receptor antibody

Immunogen

Human SORL1 Recombinant protein (His tag)

Isotype

Rabbit IgG

Preparation

This antibody was obtained by immunization of SORLA recombinant protein (Accession Number: NM_003105). Purification method: Antigen Affinity purified.

Clonality

Polyclonal

Formulation

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions

Store at -20℃. DO NOT ALIQUOT

Applications

Recommended Dilution:

IP: 1:200-1:2000

IHC: 1:20-1:200

Validations

IP Result of anti-SORL1 (IP:Catalog No:115506, 5ug; Detection:Catalog No:115506 1:500) with mouse brain tissue lysate 10000ug.

Immunohistochemistry of paraffin-embedded human brain slide using Catalog No:115506(SORL1 Antibody) at dilution of 1:50

Background

SorLA also known as SorL1 or LR11, is a multiligand receptor belonging to the LDL receptor superfamily. It is also a member of vacuolar protein sorting-10 (Vps10) family and is enriched in the brain. SorLA acts as an sorting receptor for APP and prevents amyloidogenic processing of APP. Downregulation of SorLA has been found in patients with sporadic Alzheimer disease (AD). Currently SorLA has emerged as a potential target for AD therapy. (25404298)

References

Chen Y, Peng Y, Che P. α(2A) adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction. Proceedings of the National Academy of Sciences of the United States of America. 111(48):17296-301. 2014.

SORLA antibody

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