Human SORL1 Recombinant protein (His tag)

Human SORL1 Recombinant protein (His tag)

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Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization. {PubMed:14764453, PubMed:16174740}.

Sortilin-related receptor

C11orf32

B4DJ13

SORL1; C11orf32

E. coli

A DNA sequence encoding the human SORL1 (NP_003096.2) 1865-2214 aa was fused with the polyhistidine tag

Human

Not tested.