SMC1A antibody

SMC1A antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SMC1A Rabbit Polyclonal antibody. Positive WB detected in A431 cells, HeLa cells, K-562 cells, NIH/3T3 cells. Observed molecular weight by Western-blot: 143-150 kDa

ELISA, WB

Human, Mouse; other species not tested.

CDLS2 antibody; DKFZp686L19178 antibody; DXS423E antibody; KIAA0178 antibody; SB1.8 antibody; SMC 1 alpha antibody; SMC 1A antibody; SMC protein 1A antibody; SMC1 antibody; SMC1A antibody; SMC1alpha antibody; SMC1L1 antibody; SMCB antibody

Rabbit IgG

This antibody was obtained by immunization of SMC1A recombinant protein (Accession Number: NM_006306). Purification method: Antigen Affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Structural maintenance of chromosomes protein 1A (SMC1A) is involved in chromosome cohesion during cell cycle and in DNA repair. It is a central component of cohesin complex which is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.