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Product Name
Human SIGIRR/TIR8 (His Tag) recombinant protein
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Description
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
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Protein name
Single Ig IL-1-related receptor
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Protein short names
PRO342; MGC110992; UNQ301; TIR8; AI256711; MGC102426
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Uniprot ID
Q6IA17
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Gene Name
SIGIRR; UNQ301/PRO342
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human SIGIRR (Q6IA17-1) extracellular domain (Met 1-His 118) was expressed, fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human SIGIRR consists of 129 amino acids and has a predicted molecular mass of 14 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhSIGIRR is approximately 25-35 kDa due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human SIGIRR / TIR8 Protein (His Tag) SDS-PAGE
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