Human SIGIRR/TIR8 (Fc Tag) recombinant protein

Human SIGIRR/TIR8 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR/TIR8 was mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut. Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no SIGIRR/TIR8, with the exception of the mouse GG2EE macrophage line. Inflammation is enhanced in SIGIRR-deficient mice. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge.

Single Ig IL-1-related receptor

MGC110992; UNQ301; PRO342; MGC102426; TIR8; AI256711

Q6IA17

SIGIRR; UNQ301/PRO342

Human Cells

A DNA sequence encoding the human SIGIRR (Q6IA17-1) (Met1-His118) was expressed with the Fc region of human IgG1 at the C-terminus.

Human

The recombinant human SIGIRR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 359 amino acids and has a predicted molecular mass of 39.5 kDa. The apparent molecular mass of the protein is approximately 47-54 and 33 kDa in SDS-PAGE under reducing conditions.

(96.8+1.6) % as determined by SDS-PAGE