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Product Name
SH2D1A antibody
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Description
SH2D1A Rabbit Polyclonal antibody. Positive WB detected in mouse thymus tissue. Observed molecular weight by Western-blot: 16kd
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
DSHP antibody; Duncan disease SH2 protein antibody; EBVS antibody; FLJ18687 antibody; FLJ92177 antibody; IMD5 antibody; LYP antibody; MTCP1 antibody; SAP antibody; SH2 domain protein 1A antibody; SH2D1A antibody; SLAM assOCiated protein antibody; XLP antibody; XLPD antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of SH2D1A recombinant protein (Accession Number: NM_002351). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
mouse thymus tissue were subjected to SDS PAGE followed by western blot with Catalog No:115178(SH2D1A antibody) at dilution of 1:500
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Background
SH2D1A, also named as DSHP and SAP, is an inhibitor of the SLAM self-association. It acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. SH2D1A mediates interaction between FYN and SLAMF1. Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1).
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References
- Ding S, Liang Y, Zhao M. Decreased microRNA-142-3p/5p expression causes CD4+ T cell activation and B cell hyperstimulation in systemic lupus erythematosus. Arthritis and rheumatism. 64(9):2953-63. 2012.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"