Anti-SH2D1A/SAP Rabbit antibody

Anti-SH2D1A/SAP Rabbit antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SH2D1A/SAP Rabbit polyclonal antibody

WB

Human, Mouse, Rat

LYP; SAP; XLP; DSHP; EBVS; IMD5; XLPD; MTCP1; XLPD1; SAP/SH2D1A antibody

Rabbit IgG

Antigen: A synthetic peptide of human SH2D1A/SAP

Polyclonal

Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Store at -20°C. Stable for 12 months from date of receipt.

Swiss-Prot Acc.O60880.Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells . May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.