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Human ALK-1 / ACVRL1 (Fc Tag) recombinant protein

Cat.#: 501915

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Product Information

  • Product Name
    Human ALK-1 / ACVRL1 (Fc Tag) recombinant protein
  • Documents
  • Description
    Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
  • Protein name
    Serine/threonine-protein kinase receptor R3
  • Protein short names
    HHT; ALK1; R3; SKR3; ORW2; MGC91691; ACVRLK1; ALK-1; HHT2; SETHKIR; AI115505; ACVRL1; R-3; AI427544; TSR-I
  • Uniprot ID
    P37023
  • Gene Name
    ACVRL1; ACVRLK1; ALK1
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the N-terminal segment (Met 1-Gln 118) of the extracellular domain of human ALK1 (NP_000011.2) pro-protein was fused with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The mature recombinant human ALK1/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer comprises 335 amino acids and has a predicted molecular mass of 37.4 kDa. As a result of glycosylation, the recombinant monomer migrates as an approximately 45-50 kDa protein in SDS-PAGE under reducing conditions.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    1. Measured by its ability to bind Human ENG-Fc (Cat:504243) in functional Elisa.
    2. Measured by its ability to latent TGFB1-His (Cat:503624) in functional Elisa.
    3. Measured by its ability to mouse ENG-His (Cat:502127) in functional Elisa.
    4. Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED50 for this effect is typically 5-15 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.
  • Validations

    Human ALK-1 / ACVRL1 Protein (Fc Tag) SDS-PAGE

    Human ALK-1 / ACVRL1 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"