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Product Name
Canine ALK-1 / ACVRL1 (Fc Tag) recombinant protein
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Description
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
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Protein name
Receptor protein serine/threonine kinase
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Protein short names
TSR-I; AI115505; ACVRL1; AI427544; R-3; MGC91691; ACVRLK1; HHT2; SETHKIR; ALK-1; HHT; R3; SKR3; ALK1; ORW2
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Uniprot ID
E2R174
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Gene Name
ACVRL1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the canine ACVRL1(E2R174) (Met1-Gln119) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Canine
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Molecular weight
The recombinant canine ACVRL1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 339 amino acids and has a predicted molecular mass of 37.9 kDa. The apparent molecular mass of the protein is approximately 43-47 kDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3-E1 cells.
The ED50 for this effect is typically 5-15 ng/mL in the presence of 2 ng/mL of recombinant human BMP-9. -
Validations
Canine ALK1 / ACVRL1 Protein (Fc Tag) SDS-PAGE
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