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Product Name
Anti-ALK-1 / ACVRL1 antibody
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Description
Rabbit monoclonal to ALK-1 / ACVRL1
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Tested applications
WB, IP
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Species reactivity
Human ALK-1 / ACVRL1
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Alternative names
ACVRL1 antibody; ACVRL1 antibody; ACVRL1 antibody; ACVRLK1 antibody; ACVRLK1 antibody; AI115505 antibody; AI427544 antibody; ALK1 antibody; ALK1 antibody; ALK-1 antibody; ALK-1 antibody; HHT antibody; HHT2 antibody; MGC91691 antibody; ORW2 antibody; R3 antibody; R-3 antibody; SETHKIR antibody; SKR3 antibody; TSR-I antibody; HHT antibody; ALK1 antibody; HHT2 antibody; ORW2 antibody; SKR3 antibody; ALK-1 antibody; TSR-I antibody; ACVRLK1 antibody; Alk1 antibody; Acvrlk1 antibody; AI115505 antibody; AI427544 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human ALK-1 / ACVRL1 (rh ALK-1 / ACVRL1; NP_000011.2; Met1-Gln118).
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Clonality
Monoclonal
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Formulation
0.2 μm filtered solution in PBS with 5% trehalose
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 2-10 μg/mL
IP: 1-4 uL/mg of lysate
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Validations
ALK-1 / ACVRL1 Antibody, Rabbit MAb
ALK-1 / ACVRL1 Antibody, Rabbit MAb, Western blot
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Background
Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
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References
- French Rendu-Osler network,et al. (2004) Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France. Hum Mutat. 23(4): 289-299.
- Simon M, et al. (2006) Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous system. J Neurosurg. 104(6): 945-9.
- Argyriou L, et al. (2006) Novel mutations in the ENG and ACVRL1 genes causing hereditary hemorrhagic teleangiectasia. Int J Mol Med. 17(4):655-9.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"