Cynomolgus ALK-2 / ACVR1 (Fc Tag) recombinant protein

Cynomolgus ALK-2 / ACVR1 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been demonstrated that ALK-2 forms complex with either the BMP-2/7-bound BMPR-II or ACVR2A /ACVR2B. ALK-1 and ALK-2 presenting in the yeast Saccharomyces cerevisiae are two haspin homologues. Both ALK-1 and ALK-2 exhibit a weak auto-kinase activity in vitro, and are phosphoproteins in vivo. ALK-1 and ALK-2 levels peak in mitosis and late-S/G2. Control of protein stability plays a major role in ALK-2 regulation. The half-life of ALK-2 is particularly short in G1. Overexpression of ALK-2, but not of ALK-1, causes a mitotic arrest, which is correlated to the kinase activity of the protein. This suggests a role for ALK-2 in the control of mitosis. Endoglin is phosphorylated on cytosolic domain threonine residues by the TGF-beta type I receptors ALK-2 and ALK-5 in prostate cancer cells. Endoglin did not inhibit cell migration in the presence of constitutively active ALK-2. Defects in ALK-2 are a cause of fibrodysplasia ossificans progressiva (FOP).

Serine/threonine-protein kinase receptor

TSRI; ACVR1; ACVRLK2; ALK-2; FOP; SKR1; ACTRI; TSK7L; ACTRIA; RP23-100B18.4; ACTR-I; ALK2; ACVR; ACVR1A; ALK8; D330013D15RIK

F7A9J8

ACVR1; EGK_04456

Human Cells

A DNA sequence encoding the cynomolgus ACVR1 (F7A9J8) (Met1-Glu123) was expressed with the Fc region of human IgG1 at the C-terminus.

Cynomolgus

The recombinant cynomolgus ACVR1 is a disulfide-linked homodimer. The reduced monomer comprises 342 amino acids and has a calculated molecular mass of 38.2 KDa.The apparent molecular mass of the protein is approximately 44 and 37 KDa respectively in SDS-PAGE.

(75.3+22.3) % as determined by SDS-PAGE