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Product Name
Mouse ALK-2 / ACVR1 (His & Fc Tag) recombinant protein
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Description
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved in left-right pattern formation during embryogenesis.
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Protein name
Activin receptor type-1
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Protein short names
TSRI; ACVR1; ALK-2; FOP; ACTRI; SKR1; ACVRLK2; RP23-100B18.4; TSK7L; ACTRIA; ALK8; ALK2; ACTR-I; ACVR; ACVR1A; D330013D15RIK
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Uniprot ID
P37172
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Gene Name
Acvr1; Acvrlk2; Tgfb1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse ACVR1 (NP_031420.2) precursor (Met 1-Glu 123) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse ACVR1/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer comprises 351 amino acids with a predicted molecular mass of 40 kDa. As a result of glycosylation, it migrates as an approximately 45 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Measure by its ability to bind with human BMP2 in a functional ELISA.
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Validations
Mouse ALK-2 / ACVR1 Protein (His & Fc Tag) SDS-PAGE
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