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Product Name
Rat ALK-2 / ACVR1 (Fc Tag) recombinant protein
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Description
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
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Protein name
Activin receptor type-1
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Protein short names
ACTR-I; SKR1; TSR-I
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Uniprot ID
P80201
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Gene Name
Acvr1; Acvrlk2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat ACVR1 (P80201) (Met1-Glu123) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat ACVR1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 344 amino acids and has a predicted molecular mass of 38.5 kDa. The apparent molecular mass of the protein is approximately 43 kDa in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Rat ALK-2 / ACVR1 / ALK2 Protein (Fc Tag) SDS-PAGE
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