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Product Name
Rat SELP / P Selectin (His Tag) recombinant protein
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Description
P selectin (SELP) is a 140kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. SELP mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. P selectin is a cell adhesion molecule on the surface of activated endothelial cells. Cellular adhesion molecules are a large family of proteins that attach the cytoskeleton and intracellular signaling cascades with the extracellular environment. SELP is a calcium-dependent receptor for myeloid cells that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interacton of activated endothelial cells or platelets with leukocytes.
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Protein name
Selp protein
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Protein short names
RP1-86F14.2; GMP-140; GRANULE MEMBRANE PROTEIN 140; CD62P; GMP140; PLATELET ACTIVATION DEPENDENT GRANULE-EXTERNAL MEMBRANE PROTEIN; CD62 ANTIGEN-LIKE FAMILY MEMBER P; PSEL; P-SELECTIN; CD62; LECAM3; LEUKOCYTE-ENDOTHELIAL CELL ADHESION MOLECULE 3; GRMP; PADGEM
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Uniprot ID
Q3MID1
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Gene Name
Selp
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat SELP (AAI01920.1) (Met1-Gln700) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat SELP comprises 670 amino acids and predicts a molecular mass of 73.4 kDa. The apparent molecular mass of the recombinant protein is approximately 114 kDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Rat SELP / selectin P / P-selectin Protein (His Tag) SDS-PAGE
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