Human SELP / P Selectin (His Tag) recombinant protein

Cat.#: 504222

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Product Information

  • Product Name
    Human SELP / P Selectin (His Tag) recombinant protein
  • Documents
  • Description
    P selectin (SELP) is a 140kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. SELP mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. P selectin is a cell adhesion molecule on the surface of activated endothelial cells. Cellular adhesion molecules are a large family of proteins that attach the cytoskeleton and intracellular signaling cascades with the extracellular environment. SELP is a calcium-dependent receptor for myeloid cells that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interacton of activated endothelial cells or platelets with leukocytes.
  • Protein name
    P-selectin
  • Protein short names
    GRMP; PADGEM; LEUKOCYTE-ENDOTHELIAL CELL ADHESION MOLECULE 3; LECAM3; CD62 ANTIGEN-LIKE FAMILY MEMBER P; PSEL; P-SELECTIN; CD62; PLATELET ACTIVATION DEPENDENT GRANULE-EXTERNAL MEMBRANE PROTEIN; GRANULE MEMBRANE PROTEIN 140; CD62P; GMP140; RP1-86F14.2; GMP-140
  • Uniprot ID
    P16109
  • Gene Name
    SELP; GMRP; GRMP
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human SELP (AAN06828.1) extracellular domain (Met 1-Ala 771) was fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The secreted recombinant human SELP consists of 741 amino acids and has a predicted molecular mass of 81.3 kDa. The apparent molecular mass of the protein is approximately 120 kDa in SDS-PAGE under reducing conditions due to glycosylation.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Validations

    Human SELP / selectin P / P-selectin Protein (His Tag) SDS-PAGE

    Human SELP / selectin P / P-selectin Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"