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Product Name
Human SFRP4 (His Tag) recombinant protein
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Description
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
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Protein name
Secreted frizzled-related protein 4
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Protein short names
FRPHE; FRP-4; MGC26498; SFRP4; SFRP-4
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Uniprot ID
Q6FHJ7
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Gene Name
SFRP4; FRPHE
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Source/Expression Host
CHO Stable Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human SFRP4 (NP_003005.2) (Met1-VAL346) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human SFRP4 consists 336 amino acids and predicts a molecular mass of 39 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Activity
Measured by its ability to inhibit Wnt3a induced alkaline phosphatase production by C3H10T 1/2 2A6 mouse embryonal fibroblast cells.
The ED50 for this effect is typically 2-20 μg/mL in the presence of 20 ng/mL of Wnt3a. -
Validations
Human sFRP4 Protein (His Tag) SDS-PAGE
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