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Human SFRP4 (His Tag) recombinant protein

Cat.#: 502990

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Product Information

  • Product Name
    Human SFRP4 (His Tag) recombinant protein
  • Documents
  • Description
    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.
  • Protein name
    Secreted frizzled-related protein 4
  • Protein short names
    FRPHE; FRP-4; MGC26498; SFRP4; SFRP-4
  • Uniprot ID
    Q6FHJ7
  • Gene Name
    SFRP4; FRPHE
  • Source/Expression Host
    CHO Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human SFRP4 (NP_003005.2) (Met1-VAL346) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human SFRP4 consists 336 amino acids and predicts a molecular mass of 39 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Activity
    Measured by its ability to inhibit Wnt3a induced alkaline phosphatase production by C3H10T 1/2 2A6 mouse embryonal fibroblast cells.
    The ED50 for this effect is typically 2-20 μg/mL in the presence of 20 ng/mL of Wnt3a.
  • Validations

    Human sFRP4 Protein (His Tag) SDS-PAGE

    Human sFRP4 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"