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Product Name
Anti-SFRP4 Rabbit antibody
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Description
SFRP4 Rabbit polyclonal antibody
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Tested applications
WB, ICC/IF, FC
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Species reactivity
Human, Mouse, Rat
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Alternative names
PYL; FRP-4; FRPHE; FRZB-2; sFRP-4 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human SFRP4
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000-1/5000
ICC/IF: 1/20-1/50
FC: 1/20
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Validations
Western blot detection of SFRP4 in K562,3T3,Hela cell lysates using SFRP4 Rabbit pAb(1:1000 diluted).Predicted band size:40kDa.Observed band size:53-55kDa.
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Background
Swiss-Prot Acc.Q6FHJ7.Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types . SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling . Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"