RRM2 antibody

RRM2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

RRM2 Rabbit Polyclonal antibody. Positive WB detected in K-562 cells, A431 cells, HeLa cells. Positive IP detected in K-562 cells. Positive IHC detected in human tonsillitis tissue. Observed molecular weight by Western-blot: 45kd

ELISA, WB, IHC, IP

Human,Mouse,Rat; other species not tested.

RR2 antibody; RR2M antibody; RRM2 antibody

Rabbit IgG

This antibody was obtained by immunization of RRM2 recombinant protein (Accession Number: NM_001034). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Ribonucleotide reductase M2 subunit is one of two subunits that constitute ribonucleotide reductase, the enzyme that catalyzes the conversion of ribonucleotide 5'-diphosphates into 2'-deoxyribonucleotides, a rate-limiting step in the production of 2'-deoxyribonucleoside 5'-diphosphates (dNTP) required for DNA synthesis and repair that is required for DNA synthesis and repair [PMID:20825972, 19250552]. RRM2 is only expressed during the late G1/early S phase, and degraded in late S phase, and the activity of RNR, and therefore DNA synthesis and cell proliferation, is controlled during the cell cycle by the synthesis and degradation of RRM2 subunit [PMID:3894352].