Human RPRD1B (His Tag) recombinant protein

Human RPRD1B (His Tag) recombinant protein

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Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.

Regulation of nuclear pre-mRNA domain-containing protein 1B

REGULATION OF NUCLEAR PRE-MRNA DOMAIN CONTAINING 1B; C20ORF77; RP23-396G1.1; REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 1B; DJ1057B20.2; NET60; CREPT; 2610304G08RIK; RPRD1B; RP5-1057B20.2; 2810446G03RIK; CELL CYCLE-RELATED AND EXPRESSION-ELEVATED PROTEIN IN TUMOR

Q9NQG5

RPRD1B; C20orf77; CREPT

Human Cells

A DNA sequence encoding the human RPRD1B (AAH33629.1) (Met1-Asp326) was expressed with an N-terminal polyhistidine tag.

Human

The recombinant human RPRD1B comprises 346 amino acids and has a predicted molecular mass of 39.3 kDa. The apparent molecular mass of the protein is approximately 39 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 85 % as determined by SDS-PAGE