Anti-RPRD1B antibody

Anti-RPRD1B antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse monoclonal to RPRD1B

WB

Human RPRD1B

regulation of nuclear pre-mRNA domain containing 1B antibody; RPRD1B antibody; RP5-1057B20.2 antibody; C20orf77 antibody; CREPT antibody; NET60 antibody; dJ1057B20.2 antibody; cell cycle-related and expression-elevated protein in tumor antibody; regulation of nuclear pre-mRNA domain-containing protein 1B antibody; regulation of nuclear pre-mRNA domain containing 1B antibody; Rprd1b antibody; RP23-396G1.1 antibody; 2610304G08Rik antibody; 2810446G03Rik antibody; Crept antibody; cell cycle-related and expression-elevated protein in tumor antibody; regulation of nuclear pre-mRNA domain-containing protein 1B antibody; CREPT antibody; NET60 antibody; C20orf77 antibody; dJ1057B20.2 antibody; Crept antibody; 2610304G08Rik antibody; 2810446G03Rik antibody

Mouse IgG2b

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RPRD1B (rh RPRD1B; AAH33629.1; Met1-Asp326). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

RPRD1B, together with RPRD1A, can accompany RNAP II from promoter regions to 3'-untranslated regions during transcription in vivo, predominantly interact with phosphorylated RNAP II, and can reduce CTD S5- and S7-phosphorylated RNAP II at target gene promoters. RNA polymerase II C-terminal domain (CTD) phosphorylation is important for various transcription-related processes. RPRD1B is a transcriptional regulator which enhances expression of CCND1. It also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A.

• Ni Z. et al., 2011, Transcription. 2 (5): 237-42.
• Kristensen AR. et al., 2012, Nat Methods. 9 (9): 907-9.
• Woods NT. et al., 2012, Sci Signal.5 (242): rs6.