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Product Name
Rat HER3/ErbB3 (Fc Tag) recombinant protein
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Description
Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.
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Protein name
Receptor tyrosine-protein kinase erbB-3
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Protein short names
C-ERBB-3; MDA-BF-1; C-ERBB3; MGC117742; P85-SERBB3; P45-SERBB3; ERBB3; ERBB-3; ERBB3R; LCCS2; MGC88033; ERBB3-S; C76256; P180-ERBB3; HER3
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Uniprot ID
Q62799
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Gene Name
Erbb3
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat ERBB3 (Q62799) (Met1-His641) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat ERBB3/Fc is a disulfide-linked homodimer. The reduced monomer comprises 863 amino acids and has a predicted molecular mass of 95.5 kDa. The apparent molecular mass of the protein is approximately 115 kDa in SDS-PAGE under reducing conditions.
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Purity
> 80 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA.
1. Immobilized rat ERBB3-Fc (Cat: 502067) at 10 μg/ml (100 μl/well) can bind biotinylated human NRG1 (isoform Beta1) (Cat: 503891) with a linear range of 0.018-0.125 μg/ml.
2. Immobilized rat ERBB3-Fc (Cat: 502067) at 10 μg/ml (100 μl/well) can bind biotinylated human NRG1 (aa 2-246)-Fc (Cat: 504102) with a linear range of 0.018-0.25 μg/ml. -
Validations
Rat HER3 / ErbB3 Protein (Fc Tag) SDS-PAGE
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