Human HER3/ErbB3 (Fc Tag) recombinant protein

Human HER3/ErbB3 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

Receptor tyrosine-protein kinase erbB-3

LCCS2; MGC88033; ERBB3R; C76256; ERBB3-S; P180-ERBB3; HER3; C-ERBB-3; MDA-BF-1; C-ERBB3; P45-SERBB3; MGC117742; P85-SERBB3; ERBB-3; ERBB3

P21860

ERBB3; HER3

Human Cells

A DNA sequence encoding the extracellular domain (Met 1-Thr 643) of human ErbB3 (NP_001973.2) precursor was expressed with the C-terminal fused Fc region of human IgG1.

Human

The mature recombinant human ErbB3/Fc chimera is a disulfide-linked homodimeric protein after the removal of signal peptide. The monomer consists of 862 amino acids and has a calculated molecular mass of 95.4 kDa. As a result of glycosylation, the recombinant monomer migrates as an approximately 130-140 kDa protein in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE

Measure by its ability to bind with human NRG1-β1 in a functional ELISA.