Human HER3/ErbB3 (His Tag) recombinant protein

Cat.#: 503568

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Product Information

  • Product Name
    Human HER3/ErbB3 (His Tag) recombinant protein
  • Documents
  • Description
    ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.
  • Protein name
    Receptor tyrosine-protein kinase erbB-3
  • Protein short names
    C76256; ERBB3-S; LCCS2; MGC88033; ERBB3R; HER3; P180-ERBB3; MDA-BF-1; C-ERBB3; C-ERBB-3; ERBB-3; ERBB3; P45-SERBB3; MGC117742; P85-SERBB3
  • Uniprot ID
    P21860
  • Gene Name
    ERBB3; HER3
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-Thr 643) of human ErbB3 (NP_001973.2) precursor was expressed, with a C-terminal polyhistidine tag.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human ErbB3 protein consists of 635 amino acids after the removal of signal peptide and has a calculated molecular mass of 70.2 kDa. As a result of glycosylation, the recombinant ErbB3 migrates as an approximately 100-110 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    1. Measured by its binding ability in a functional ELISA.
    2. Immobilized human ErbB3 at 2 μg/mL (100 μl/well) can bind human NRG1 (isoform Beta1), The EC50 of human NRG1 (isoform Beta1) is 0.43 μg/mL.
  • Validations

    Human HER3 / ErbB3 Protein (His Tag) SDS-PAGE

    Human HER3 / ErbB3 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"