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Product Name
Mouse EPHA3/Eph Receptor A3 (Fc Tag) recombinant protein
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Description
EPHA3 gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EPHA3 gene encodes a protein that binds ephrin-A ligands. EPHA3 is involved in the retinotectal mapping of neurons. It may also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
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Protein name
Receptor protein-tyrosine kinase
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Protein short names
TYROSINE-PROTEIN KINASE TYRO4; TYRO4; EPH RECEPTOR A3; TYRO4 PROTEIN TYROSINE KINASE; HEK4; ETK; EPHRIN TYPE-A RECEPTOR 3; MEK4; CEK4; END3; EPH-LIKE KINASE 4; EPHA3; HUMAN EMBRYO KINASE 1; EPH-LIKE TYROSINE KINASE 1; EK4; AW492086; ETK1; TYROSINE-PROTEIN KINASE RECEPTOR ETK1; HEK
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Uniprot ID
Q8BRB1
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Gene Name
Epha3
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse EPHA3 (NP_034270.1)(Met1-His541) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse EPHA3/Fc comprises 762 amino acids and has a predicted molecular mass of 85.7 kDa. The apparent molecular mass of the protein is approximately 96 kDa in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA.
Immobilized mouse EFNA5-His (Cat:503820) at 10 μg/ml (100 μl/well) can bind mouse EPHA3-Fc, The EC50 of rat mouse EPHA3-Fc is 12.3-28.9 ng/ml. -
Validations
Mouse EphA3 Protein (Fc Tag) SDS-PAGE
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