Rat IL-17R/IL-17RA ?CD217? (His Tag) recombinant protein

Rat IL-17R/IL-17RA ?CD217? (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

Protein Il17ra

IL17R; CDW217; HIL-17R; IL-17R; IL-17RA; AW538159; MGC10262; VDW217; IL17RA; CD217; CANDF5

D4A740

Il17ra

Human Cells

A DNA sequence encoding the rat IL17RA (NP_001101353.2) (Met1-Pro320) was expressed, fused with a polyhistidine tag at the C-terminus.

Rat

The recombinant rat IL17RA comprises 300 amino acids and predicts a molecular mass of 34.1 kDa. The apparent molecular mass of the recombinant protein is approximately 52-58 kDa in SDS-PAGE under reducing conditions due to glycosylation.

> 95 % as determined by SDS-PAGE

1. Measured by its binding ability in a functional ELISA. Immobilized rat IL17RA-His at 10 μg/ml (100 μl/well) can bind biotinylated human IL17A (Cat:503539), The EC₅₀ of biotinylated human IL17A (Cat:503539) is 5-11.8 ng/ml.
2.Measured by its binding ability in a functional ELISA. Immobilized mouse IL17a (Cat:503385) at 10 μg/ml (100 μl/well) can bind rat IL17RA-His, The EC₅₀ of rat IL17RA-His is 0.44-1.02 μg/mL.