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Human IL-17R/IL-17RA ?CD217? (His Tag) recombinant protein

Cat.#: 502662

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Product Information

  • Product Name
    Human IL-17R/IL-17RA ?CD217? (His Tag) recombinant protein
  • Documents
  • Description
    Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.
  • Protein name
    Interleukin-17 receptor A
  • Protein short names
    VDW217; MGC10262; CD217; CANDF5; IL17RA; HIL-17R; CDW217; IL17R; AW538159; IL-17RA; IL-17R
  • Uniprot ID
    Q96F46
  • Gene Name
    IL17RA; IL17R
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain of human IL17RA (NP_055154.3) (Met 1-Trp 320) was fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human IL17RA consists of 299 amino acids and has a predicted molecular mass of 35 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh IL17RA is approximately 55-60 kDa due to glycosylation.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    1. Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL17A at 2 μg/ml (100 μl/well) can bind biotinylated human IL17RA with a linear range of 1.28-32 ng/ml.
    2. Measured by its ability to inhibit IL-17-induced IL-6 secretion by HFF human foreskin fibroblast cells. The ED50 for this effect is typically 0.03-0.12 μg/mL.
  • Validations

    Human IL17RA / CD217 Protein (His Tag) SDS-PAGE

    Human IL17RA / CD217 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"