Human IL-17R/IL-17RA ?CD217? (His & Fc Tag) recombinant protein

Human IL-17R/IL-17RA ?CD217? (His & Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

Interleukin-17 receptor A

IL17R; CDW217; HIL-17R; IL-17R; AW538159; IL-17RA; MGC10262; VDW217; CANDF5; CD217; IL17RA

Q96F46

IL17RA; IL17R

Human Cells

A DNA sequence encoding the extracellular domain of human IL17RA (NP_055154.3) (Met 1-Trp 320) was was fused with the C-terminal polyhistidine-taggged Fc region of human IgG1 at the C-terminus.

Human

The recombinant human IL17RA/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 536 amino acids and has a predicted molecular mass of 61.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh IL17RA/Fc monomer is approximately 95-105 kDa due to glycosylation.

> 85 % as determined by SDS-PAGE

1. Measured by its ability to bind human IL17F in a functional ELISA.
2. Measured by its binding ability in a functional ELISA.
3. Immobilized recombinant human IL17A at 20 μg/ml (100 μl/well) can bind human IL17RA with a linear range of 32-160 ng/ml.