Rat EpCAM/TROP-1/TACSTD1 (Fc Tag) recombinant protein

Rat EpCAM/TROP-1/TACSTD1 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

Epithelial cell adhesion molecule

KSA; EGP314; CD326; MK-1; EP-CAM; GA733-2; M4S1; HEGP-2; LY74; CO17-1A; TACSD1; ESA; TACST-1; DIAR5; GP40; EGP34; TACSTD1; CO-17A; MIC18; EGP; HNPCC8; TROP1; KS1/4; EGP40; EPCAM; EGP-2; EPCAM1

O55159

Epcam; Tacstd1

Human Cells

A DNA sequence encoding the rat EPCAM (O55159) (Met1-Thr266) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Rat

The recombinant rat EPCAM/Fc is a disulfide-linked homodimer. The reduced monomer comprises 484 amino acids and has a predicted molecular mass of 54.8 kDa. The apparent molecular mass of the protein is approximately 61 and 37 kDa in SDS-PAGE under reducing conditions.

> 98 % as determined by SDS-PAGE