Human EpCAM/TROP-1/TACSTD1 (Fc Tag) recombinant protein

Human EpCAM/TROP-1/TACSTD1 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

EGP-2; EPCAM1; KS1/4; TROP1; EPCAM; EGP40; MIC18; EGP; CO-17A; HNPCC8; DIAR5; EGP34; TACSTD1; GP40; TACSD1; HEGP-2; CO17-1A; LY74; M4S1; ESA; TACST-1; CD326; KSA; EGP314; GA733-2; EP-CAM; MK-1

P16422

Human Cells

A DNA sequence encoding the extracellular domain (Met 1-Lys265) of human EpCAM (NP_002345.1) was expressed with the fused Fc region of human IgG1 at the C-terminus.

Human

The recombinant human EpCAM/Fc chimera is a disulfide-linked homodimeric protein after removal of the signal peptide. The monomer consists of 480 amino acids and has a calculated molecular mass of 54 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh EpCAM/Fc is approximately 65-70 kDa due to glycosylation.

> 95 % as determined by SDS-PAGE