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Product Name
Rat CDH13 / Cadherin-13 / H Cadherin (Fc Tag) recombinant protein
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Description
CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer.
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Protein name
Cadherin 13
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Protein short names
H-CADHERIN (HEART); T-CADHERIN; CDHT; T-CAD; CDH13; 4932416G01RIK; HEART CADHERIN; CDHH; CADHERIN 13; TCAD; H-CADHERIN; P105
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Uniprot ID
Q8R490
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Gene Name
Cdh13; rCG_51389
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat CDH13 (NP_620244.1)(Met1-Ala692) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat CDH13/Fc is a disulfide-linked homodimer. The reduced monomer comprises 912 amino acids and has a predicted molecular mass of 100.5 kDa. The apparent molecular mass of the protein is approximately 102 and 52 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
(53+40.8) % as determined by SDS-PAGE
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Validations
Rat CDH13 / Cadherin-13 / H Cadherin Protein (Fc Tag) SDS-PAGE
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