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Product Name
Anti-CDH13 / Cadherin-13 / H Cadherin antibody
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Description
Rabbit polyclonal to CDH13 / Cadherin-13 / H Cadherin
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Tested applications
ELISA, WB, IP
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Species reactivity
Mouse CDH13 / Cadherin-13 / H Cadherin
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Alternative names
cadherin 13 antibody; H-cadherin (heart) antibody; CDH13 antibody; CDHH antibody; P105 antibody; H-cadherin antibody; T-cad antibody; T-cadherin antibody; heart cadherin antibody; cadherin 13 antibody; Cdh13 antibody; 4932416G01Rik antibody; Cdht antibody; T-cadherin antibody; Tcad antibody; H-cadherin antibody; T-cad antibody; heart cadherin antibody; CDHH antibody; P105 antibody; Cdht antibody; Tcad antibody; T-cadherin antibody; 4932416G01Rik antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Mouse CDH13 / Cadherin-13 / H Cadherin (rh CDH13 / Cadherin-13 / H Cadherin; NP_062681.2; Met1-Ala692). CDH13 / Cadherin-13 / H Cadherin specific IgG was purified by Mouse CDH13 / Cadherin-13 / H Cadherin affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 10-20 μg/ml
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CDH13 / Cadherin-13 / H Cadherin. The detection limit for Mouse CDH13 / Cadherin-13 / H Cadherin is < 0.039 ng/well.
IP: 1-4 μg/mg of lysate
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Validations
CDH13 / Cadherin-13 / H Cadherin Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
CDH13 / Cadherin-13 / H Cadherin Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
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Background
CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer.
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References
- Hart AB. et al., 2012, PLoS One. 7 (8): e42646.
- Xu J. et al., 2012, BMC Cancer. 12: 243.
- Jo J. et al., 2012, Obesity (Silver Spring). 20 (8): 1683-7.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"