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Product Name
Rat Thrombomodulin / THBD (His Tag) recombinant protein
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Description
Thrombomodulin, also known as THBD(CD141), is an integral membrane protein which reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It is also expressed on human mesothelial cell, monocyte and a dendritic cell subset. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. Thrombomodulin also regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene have also been reported to be associated with atypical hemolytic-uremic syndrome.
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Protein name
Protein Thbd
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Protein short names
CD141; THROMBOMODULIN; THRM; SNORNA MBII-339; THPH12; AI385582; RP23-70N3.2; THBD; AHUS6; FETOMODULIN; TM; CD141 ANTIGEN; BDCA3
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Uniprot ID
O35370
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Gene Name
Thbd; rCG_27567
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rat THBD (O35370) (Met1-Ser517) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Rat
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Molecular weight
The recombinant rat THBD comprises 512 amino acids and predicts a molecular mass of 55.2 kDa. The apparent molecular mass of the recombinant protein is approximately 95 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Rat Thrombomodulin / THBD Protein (His Tag) SDS-PAGE
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