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Product Name
Anti-Thrombomodulin / THBD antibody
- Documents
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Description
Rabbit monoclonal to Thrombomodulin / THBD
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Tested applications
IHC-P
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Species reactivity
Rat Thrombomodulin / THBD
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Alternative names
TM antibody; THRM antibody; AHUS6 antibody; BDCA3 antibody; CD141 antibody; THPH12 antibody; TM antibody; CD141 antibody; AI385582 antibody; AHUS6 antibody; AI385582 antibody; BDCA3 antibody; CD141 antibody; CD141 antibody; CD141 antigen antibody; fetomodulin antibody; fetomodulin antibody; RP23-70N3.2 antibody; snoRNA MBII-339 antibody; THBD antibody; Thbd antibody; THPH12 antibody; THRM antibody; Thrombomodulin antibody; Thrombomodulin antibody; TM antibody; TM antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Rat Thrombomodulin / THBD (rR Thrombomodulin / THBD; O35370; Met1-Ser517).
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Clonality
Monoclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
IHC-P: 0.5-5 μg/mL
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Validations
Thrombomodulin / THBD Antibody, Rabbit MAb, Immunohistochemistry
Immunochemical staining of rat THBD in rat lung with rabbit monoclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Thrombomodulin / THBD Antibody, Rabbit MAb, Immunohistochemistry
Immunochemical staining of rat THBD in rat liver with rabbit monoclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
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Background
Thrombomodulin, also known as THBD(CD141), is an integral membrane protein which reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It is also expressed on human mesothelial cell, monocyte and a dendritic cell subset. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. Thrombomodulin also regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene have also been reported to be associated with atypical hemolytic-uremic syndrome.
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References
- Dzionek A, et al. (2002) Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions. Hum Immunol. 63(12):1133-48.
- Dzionek A, et al. (2000) BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol. 165(11):6037-46.
- Wen DZ, et al. (1987) Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene. Biochemistry. 26(14):4350-7.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"