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  • Phospho-GRIN2B-Y1474 pAb
  • Phospho-GRIN2B-Y1474 pAb

Phospho-GRIN2B-Y1474 pAb

Cat.#: 166412

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Product Information

  • Product Name
    Phospho-GRIN2B-Y1474 pAb
  • Documents
  • Description
    Polyclonal antibody to Phospho-GRIN2B-Y1474
  • Tested applications
    WB, IF
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    GRIN2B antibody; EIEE27 antibody; GluN2B antibody; MRD6 antibody; NMDAR2B antibody; NR2B antibody; hNR3 antibody; glutamate receptor ionotropic, NMDA 2B antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A phospho specific peptide corresponding to residues surrounding Y1474 of human GRIN2B
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IF 1:100 - 1:200
  • Validations

    Western blot - Phospho-GRIN2B-Y1474 pAb

    Western blot - Phospho-GRIN2B-Y1474 pAb

    Western blot analysis of extracts from A431 cells, using Phospho-GRIN2B-Y1474 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% BSA.

    Immunofluorescence - Phospho-GRIN2B-Y1474 pAb

    Immunofluorescence - Phospho-GRIN2B-Y1474 pAb

    Immunofluorescence analysis of methanol-fixed HeLa cells using Phospho-GRIN2B-Y1474 antibody .

  • Background
    Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"