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Product Name
Human GRIN2B Recombinant protein (His tag)
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Description
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
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Protein name
Glutamate receptor ionotropic, NMDA 2B
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Protein short names
NMDAR2B
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Uniprot ID
Q13224
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Gene Name
GRIN2B; NMDAR2B
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human GRIN2B (XP_054227830.1) 1133-1484 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human GRIN2B SDS-PAGE
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