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Product Name
PEX19 antibody
- Documents
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Description
PEX19 Rabbit Polyclonal antibody. Positive IHC detected in human gliomas tissue. Positive WB detected in human heart tissue, rat heart tissue. Positive IP detected in K-562 cells. Observed molecular weight by Western-blot: 35-40 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human, Mouse, Rat; other species not tested.
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Alternative names
33 kDa housekeeping protein antibody; D1S2223E antibody; HK33 antibody; Peroxin 19 antibody; PEX19 antibody; PMP1 antibody; PMPI antibody; PXF antibody; PXMP1 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PEX19 recombinant protein (Accession Number: NM_002857). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:1000
IHC: 1:20-1:200
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Validations
WB result of Catalog No:113729 (PEX19 antibody) with several lysates.
human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:113729(PEX19 antibody) at dilution of 1:300
Immunohistochemical of paraffin-embedded human gliomas using Catalog No:113729(PEX19 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human gliomas using Catalog No:113729(PEX19 antibody) at dilution of 1:100 (under 40x lens)
IP Result of anti-PEX19 (IP:Catalog No:113729, 3ug; Detection:Catalog No:113729 1:300) with K-562 cells lysate 2400ug.
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Background
Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. PEX19 gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs) (PMID: 14709540). PEX19 may bind newly synthesized PMPs and facilitate their insertion into the peroxisome membrane (PMID: 107044440. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14) (PMID:20683989) (PMID:10051604).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"