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Product Name
Human PEX19 Recombinant protein (GST tag)
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Description
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. {PubMed:10051604, PubMed:10704444, PubMed:11259404, PubMed:11883941, PubMed:14709540, PubMed:15007061}.
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Protein name
Peroxisomal biogenesis factor 19
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Protein short names
HK33; PXF
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Uniprot ID
P40855
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Gene Name
PEX19; HK33; PXF; OK/SW-cl.22
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human PEX19 (NP_002848.1) 1-299 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human PEX19(Full length) SDS-PAGE
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