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Product Name
PDE1C antibody
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Description
PDE1C Rabbit Polyclonal antibody. Positive IP detected in mouse heart tissue. Positive WB detected in human heart tissue. Observed molecular weight by Western-blot: 68 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
Cam PDE 1C antibody; hCam 3 antibody; Hcam3 antibody; PDE1C antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PDE1C recombinant protein (Accession Number: NM_005020). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
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Validations
human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:113658(PDE1C antibody) at dilution of 1:500
IP Result of anti-PDE1C (IP:Catalog No:113658, 4ug; Detection:Catalog No:113658 1:500) with mouse heart tissue lysate 4000ug.
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Background
Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. PDE1C, is calmodulin-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex. Expression of PDE1C may be an important component in signal transduction pathways mediated by calcium that permit cell cycle traverse and proliferation(PMID:9366577). It has 2 isoforms produced by alternative splicing.
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