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Mouse NOTCH1 (Fc Tag) recombinant protein

Cat.#: 501554

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Product Information

  • Product Name
    Mouse NOTCH1 (Fc Tag) recombinant protein
  • Documents
  • Description
    Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
  • Protein name
    Neurogenic locus notch homolog protein 1
  • Protein short names
    RP23-306D20.12-001; HN1; MAJOR TYPE A PROTEIN; MT14; N1; AOVD1; TAN1; MOTCH A; AOS5; MIS6; 9930111A19RIK; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1; LIN-12
  • Uniprot ID
    Q01705
  • Gene Name
    Notch1; Motch
  • Source/Expression Host
    CHO Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse Notch1 (NP_032740.3) (Met1-Gln526) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse Notch1 consists 749 amino acids and predicts a molecular mass of 80.6 kDa.
  • Purity
    > 90 % as determined by SDS-PAGE.
  • Validations

    Mouse Notch-1 / NOTCH1 Protein (,Fc Tag)

    Mouse Notch-1 / NOTCH1 Protein (,Fc Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"