Anti-Notch1 Rabbit antibody

Cat.#: 167103

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-Notch1 Rabbit antibody
  • Documents
  • Description
    Notch1 Rabbit polyclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, FC
  • Species reactivity
    Human, Mouse
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthesized peptide derived from human Notch1
  • Clonality
    Polyclonal
  • Formulation
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/500-1/3000

    IHC: 1/50-1/200

    ICC/IF: 1/100-1/500

    FC: 1/200-1/500

  • Validations

    Immunofluorescent analysis of HeLa cells, using Notch1 Antibody .

    Immunofluorescent analysis of HeLa cells, using Notch1 Antibody .

    Western blot analysis of Notch1 expression in MCF7,Jurkat,CEM and Rat Brain cell lysates using Notch1 antibody at 1/1000 dilution.Predicted band size:125KDa.Observed band size:120,300KDa.

    Western blot analysis of Notch1 expression in MCF7,Jurkat,CEM and Rat Brain cell lysates using Notch1 antibody at 1/1000 dilution.Predicted band size:125KDa.Observed band size:120,300KDa.

    Western blot analysis of NOTCH1 expression in HEK293 cell lysate.

    Western blot analysis of NOTCH1 expression in HEK293 cell lysate.

    Immunohistochemical analysis of paraffin-embedded human liver, using Notch1 Antibody .

    Immunohistochemical analysis of paraffin-embedded human liver, using Notch1 Antibody .

  • Background
    Swiss-Prot Acc.P46531.Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"