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Product Name
Human UBE2M recombinant protein
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Description
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
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Protein name
NEDD8-conjugating enzyme Ubc12
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Protein short names
UBC12; 2510040H03RIK; HUBC12; UBC-RS2
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Uniprot ID
P61081
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Gene Name
UBE2M; UBC12
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human UBE2M (P61081) (Met 1-Lys 183) was expressed and purified, with additional two amino acids (Gly & Pro) at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human UBE2M consists of 185 amino acids and has a calculated molecular mass of 21 kDa. It migrates as an approximately 20 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human UBE2M Protein SDS-PAGE
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